[Data-modeling] Additional properties to Disease/Physician

[Benjamin Good]

Sorry I haven't been contributing much, but please do cc me if you can  
remember.

thanks
-Ben


On Jun 6, 2008, at 12:08 PM, Faye Li wrote:

> Since it's so specialized, I'm offling this discussion with Dan. If
> anyone is interested in getting involved in the discussion, email me
> directly to get cc'd on.
>
> -- Faye
>
>
> Dan Ruderman wrote:
>> Hi Faye,
>>
>>
>>> 1) Type: "Disease or medical condition"
>>> New property: "Associated Genes", with expected type "Gene"
>>> Reverse property on type "Gene" will be "Associated  
>>> Diseases" (will be
>>> done once I get a Biology domain admin to help)
>>>
>>> For example, Huntington Disease is associated with the hungtingtin  
>>> gene:
>>> http://sandbox.freebase.com/view/guid/9202a8c04000641f800000000005ead2
>>>
>>>
>>>
>> Two comments on this.   First, people are more and more
>> associating gene groups (say, that belong to a particular
>> pathway) with diseases.   So you might want to think about
>> an additional property relating diseases to the gene group type.
>> Second, though it is a bit more work, it would be more
>> scientifically useful to connect the gene and the disease
>> though a relationship, like the way a drummer relates to
>> a band though band membership.  This way the relationship
>> between disease and gene can be annotated (e.g. it was stated
>> in these publications, or on this web site).   My concern is
>> that what we think is true today may not be true tomorrow,
>> so you ideally want to track who is saying what rather than state
>> it as fact.  This makes the data model more complicated, but it might
>> be worth the hassle.
>>
>>
>>> Question: Would it be useful to also add a (unique?) property
>>> "Cytogenetic Band" (expected type "Cytogenetic Band") to the Disease
>>> type? And if so, would a reverse property from "Cytogenetic Band"  
>>> back
>>> to "Disease" make sense? It would be trivial for me to add both.  
>>> In the
>>> case of "Huntington Disease", the property would point to the "Human
>>> Cytogenetic Band 4p16.3" topic:
>>> http://sandbox.freebase.com/view/guid/9202a8c04000641f80000000051dc7bc
>>>
>>>
>> For genes implicated in disease, the cytogenetic band can be
>> determined from the locus property on the gene itself.  However,
>> there are diseases which implicate entire chromosomal regions,
>> like cancer (e.g. http://progenetix.net/progenetix/).  But the
>> involvement of any given chromosomal region might depend on
>> the stage of the cancer, and the particular tumor you are looking
>> at.
>>
>> I'd be happy to discuss any more thoughts on either of these
>> issues off-line.
>>
>> Best,
>> Dan
>>
>> _______________________________________________
>> Data-modeling mailing list
>> Data-modeling at freebase.com
>> http://lists.freebase.com/mailman/listinfo/data-modeling
>>
>>
>
> _______________________________________________
> Data-modeling mailing list
> Data-modeling at freebase.com
> http://lists.freebase.com/mailman/listinfo/data-modeling